FAT10 knock out mice livers fail to develop Mallory–Denk bodies in the DDC mouse model
نویسندگان
چکیده
منابع مشابه
The p47phox mouse knock-out model of chronic granulomatous disease
Chronic granulomatous disease (CGD) is caused by a congenital defect in phagocyte reduced nicotinamide dinucleotide phosphate (NADPH) oxidase production of superoxide and related species. It is characterized by recurrent life-threatening bacterial and fungal infections and tissue granuloma formation. We have created a mouse model of CGD by targeted disruption of p47phox, one of the genes in whi...
متن کاملMice knock out for the histone acetyltransferase p300/CREB binding protein-associated factor develop a resistance to amyloid toxicity.
p300/CREB binding protein-associated factor (PCAF) regulates gene expression by acting through histone acetylation and as a transcription coactivator. Although histone acetyltransferases were involved in the toxicity induced by amyloid-beta (Abeta) peptides, nothing is known about PCAF. We here analyzed the sensitivity of PCAF knockout (KO) mice to the toxic effects induced by i.c.v. injection ...
متن کاملEstrogen and pain: a study in aromatase knock-out mice using the formalin model
In order to study the role of gender and estrogens on inflammatory pain, we compared sensitivity to formalin injected in the lip between male and female estrogen-deficient aromatase knock-out mice (ArKO) and their wild-type littermates (WT). No difference in nociceptive behaviour was observed between male and female WT mice. By contrast, lip rubbing was significantly more pronounced in ArKO tha...
متن کاملBehavioral state instability in orexin knock-out mice.
Narcolepsy is caused by a lack of orexin (hypocretin), but the physiologic process that underlies the sleepiness of narcolepsy is unknown. Using orexin knock-out (KO) mice as a model of narcolepsy, we critically tested the three leading hypotheses: poor circadian control of sleep and wakefulness, inadequate activation of arousal regions, or abnormal sleep homeostasis. Compared with wild-type (W...
متن کاملPotentiated opioid analgesia in norepinephrine transporter knock-out mice.
Several studies have shown that activation of alpha(2)-adrenergic receptors (alpha(2)ARs) leads to mild analgesic effects. Tricyclic antidepressants (TCAs), such as desipramine (DMI), which block norepinephrine transporters (NETs), also produce mild antinociception. The coadministration of either alpha(2)AR agonists or TCAs with opiates produces synergistically potentiated antinociception. It h...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Experimental and Molecular Pathology
سال: 2012
ISSN: 0014-4800
DOI: 10.1016/j.yexmp.2012.09.002